anadrol reviews

Myotropic antispasmodic. On chemical structure and pharmacological properties similar to papaverine, but has a strong and lasting effect. Reduces the flow of calcium ions into smooth muscle cells (inhibits phosphodiesterase, anadrol reviews leads to the accumulation of intracellular cAMP). It lowers the tone of smooth muscles of internal organs and intestinal peristalsis, dilates blood vessels. No effect on the autonomic system can not penetrate into the central nervous system.
Having a direct effect on the smooth muscles permit use as spasmolytic when contraindicated drugs from the group M-anticholinergics (angle-closure glaucoma, prostatic hyperplasia).

In oral absorption – high period poluabsorbtsii -12 min. Bioavailability – 100%. Evenly distributed in the body, it enters the smooth muscle cells. The time to reach maximum concentration in the blood -2 hours Connection with the plasma protein -. 95-98%. Mainly excreted by the kidneys, to a lesser extent – in the bile. It does not cross the blood-brain barrier.

Indications
Prevention and treatment of functional states, and pain associated with spasm of smooth muscles in chronic gastroduodenitis, chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, gastric ulcer and 12 duodenal ulcer, cardiovascular and pilorospazme, spastic colitis; spasms of the peripheral arteries, anadrol reviews the cerebral vessels; Renal stone disease; algodismenorreya; to weaken uterine contractions and cervical spasm relief in childbirth; during the instrumental studies.

Contraindications
: Hypersensitivity to the drug, pronounced liver, kidney, heart failure; atrioventricular block II-III degree, cardiogenic shock, hypotension. Be wary appoint patients with severe atherosclerosis of the coronary arteries, hyperplasia of the prostate, glaucoma, during pregnancy and lactation.

Dosing and Administration
Inside. Adults – by 40-80 mg 2-3 times a day. Children under 6 years – 10-20 mg, from 6 to 12 years – 20 mg 1-2 times a day.

Side effects:
dizziness, palpitation, reduction in blood pressure, feeling of heat, sweating, allergic skin reactions.

Overdose
In large doses, violates the atrioventricular conduction, reduces the excitability of the heart muscle can cause heart failure and paralysis of the respiratory center.

Interaction with other drugs
With simultaneous use may weaken the antiparkinsonian effect of levodopa. It enhances the effect of papaverine, bendazol and other antispasmodics (including M-anticholinergics). It enhances the reduction in blood pressure caused by tricyclic antidepressants, quinidine and procainamide. Reduces anadrol reviews spazmogennoe morphine activity.
Phenobarbital increases the severity of antispasmodic action Drotaverinum hydrochloride.

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